Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer’s model of adult zebrafish brain
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چکیده
منابع مشابه
Radial Glia and Neurogenesis in the Embryonic Zebrafish Hindbrain
This thesis is an investigation of the behaviour of radial progenitors in the hindbrain of the teleost fish Danio rerio, the zebrafish, during embryonic neurogenesis. These progenitors have many of the characteristics of radial glial cells described in other systems. Recent studies from several laboratories worldwide have shown that radial glia play an important role in the patterning and neuro...
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The idea that the adult brain retains the capacity to generate new neurons has been proposed several times over the last 40 years, and in each case both conceptual and technical constraints have led to resistance. Joseph Altman first reported that some dividing cells in the adult brain survived and differentiated into cells with morphology similar to neurons using tritiated thymidine autoradiog...
متن کاملNeuron-glia synapses in the brain.
The ability to investigate the electrophysiological properties of individual cells in acute brain tissue led to the discovery that many glial cells have the capacity to respond rapidly to neuronal activity. In particular, a distinct class of neuroglial cells known as NG2 cells, which exhibit many of the properties that have been described for glial subtypes such as complex cells, polydendrocyte...
متن کاملRegeneration of Zebrafish CNS: Adult Neurogenesis
Regeneration in the animal kingdom is one of the most fascinating problems that have allowed scientists to address many issues of fundamental importance in basic biology. However, we came to know that the regenerative capability may vary across different species. Among vertebrates, fish and amphibians are capable of regenerating a variety of complex organs through epimorphosis. Zebrafish is an ...
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ژورنال
عنوان ژورنال: PLOS Biology
سال: 2020
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.3000585